2. Gene
  3. Vcp - valosin-containing protein Gene

Vcp - valosin-containing protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 116643 | Gene type: protein coding

About Vcp

Primary_assembly 5: 57,210,168-57,229,571 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 229 orthologues, 6 paralogues and is associated with 25 phenotypes. Biased expression in Heart (RPKM 1161.1), Muscle (RPKM 181.6) and 9 other tissues.

Summary

Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of synapse organization. Located in cytosol and endoplasmic reticulum. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Vcp Products(1)

mRNA Protein Name
NM_053864.2 NP_446316.1 transitional endoplasmic reticulum ATPase

Vcp Protein Structure

CDC48

CDC48: cl36852 (24 - 763)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

transitional endoplasmic reticulum ATPase

15S Mg(2+)-ATPase p97 subunit

TER ATPase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12861 CB-5083 Inhibitor 99.90% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15713 NMS-873 Inhibitor 99.87% Unkown
HY-123872 MSC1094308 Inhibitor 99.89% Unkown
HY-128870 Mal-PEG2-VCP-Eribulin 99.82% Unkown
HY-15714 NMS-859 Inhibitor 98.05% Unkown
HY-130084 Mal-PEG2-VCP-NB 98.25% Unkown
HY-157508 VCP Activator 1 Activator 99.71% Unkown
HY-128871 VCP-Eribulin / Unkown
HY-113608 VCP171 Modulator / Unkown
HY-124776 NPD8733 / Unkown
HY-139606 VCP/p97 inhibitor-1 Inhibitor / Unkown
HY-148122 NW 1028 Inhibitor / Unkown
HY-RS15621 VCP Human Pre-designed siRNA Set A / Unkown
HY-RS15622 Vcp Mouse Pre-designed siRNA Set A / Unkown
HY-RS15623 Vcp Rat Pre-designed siRNA Set A / Unkown
HY-N12840 Logmalicid B / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcp NCBI NCBI:7415