ARAP2 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Gene

Homo sapiens

Also known as PARX; CENTD1

Gene ID: 116984 | Gene type: protein coding

About ARAP2

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:36,005,404-36,244,784 (from NCBI)

This gene has 9 transcripts (splice variants), 126 orthologues and 28 paralogues. Broad expression in thyroid (RPKM 5.9), brain (RPKM 5.8) and 22 other tissues.

Summary

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

ARAP2 Products(1)

mRNA	Protein	Name
NM_015230.4	NP_056045.2	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

ARAP2 Protein Structure

SAM_1

ArfGap

RhoGAP

0
300
600
900
1200
1500
1704 a.a.

Protein Preferred Names

Protein Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Arf and Rho GAP adapter protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00888	ARAP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARAP2	VGNC	VGNC:59863
Mus musculus	ARAP2	MGD	MGI:2684416
Macaca mulatta	ARAP2	VGNC	VGNC:69843
Rattus norvegicus	ARAP2	RGD	RGD:1306452
Canis familiaris	ARAP2	VGNC	VGNC:38026
Bos taurus	ARAP2	VGNC	VGNC:26055

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