2. Gene
  3. DCD - dermcidin Gene

DCD - dermcidin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PIF; AIDD; DSEP; HCAP; DCD-1

Gene ID: 117159 | Gene type: protein coding

About DCD

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,644,589-54,648,365 (from NCBI)

This gene has 3 transcripts (splice variants), 17 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature Peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has Antibacterial and Antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in Cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

DCD Products(2)

mRNA Protein Name
NM_001300854.2 NP_001287783.1 dermcidin isoform 2 preproprotein
NM_053283.4 NP_444513.1 dermcidin isoform 1 preproprotein

DCD Protein Structure

Dermcidin

Dermcidin: Dermcidin, antibiotic peptide (19 - 109)

  • 0
  • 100
  • 110 a.a.
Protein Preferred Names Protein Names

dermcidin

diffusible survival/evasion peptide

Recombinant DCD Proteins

Cat. No. Product Name Accession Purity
HY-P71729 DCD Protein, Human (P.pastoris, His) P81605 (Y20-L110) ≥95%

Related Diseases

Diseases Alias
Root Caries

Cementum Caries

Dental Caries Of Root Surface
Spondylometaphyseal Dysplasia With Corneal Dystrophy

SMDCD

Spondylometaphyseal Dysplasia-Corneal Dystrophy Syndrome

Smd-Corneal Dystrophy Syndrome
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome
Cholinergic Urticaria
Angiomyoma

Vascular Leiomyoma
Miliaria

Eccrine Miliaria

Heat Rash

Sweat Rash

Sweat Retention Syndrome
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Sweat Gland Disease

Sweat Gland Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12308 TCS 2314 Antagonist ≥99.0% Unkown
HY-RS03572 DCD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99656 Iladatuzumab / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DCD NCBI
Macaca fascicularis DCD NCBI
Mus musculus DCD NCBI
Rattus norvegicus DCD NCBI
Macaca mulatta DCD NCBI