ANTXR2 - ANTXR cell adhesion molecule 2 Gene

Homo sapiens

Also known as HFS; ISH; JHF; CMG2; CMG-2

Gene ID: 118429 | Gene type: protein coding

About ANTXR2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:79,901,146-80,073,472 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 4 phenotypes. Broad expression in prostate (RPKM 24.4), endometrium (RPKM 22.7) and 21 other tissues.

Summary

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

ANTXR2 Products(4)

mRNA	Protein	Name
NM_001145794.2	NP_001139266.1	anthrax toxin receptor 2 isoform 2 precursor
NM_001286780.2	NP_001273709.1	anthrax toxin receptor 2 isoform 3
NM_001286781.2	NP_001273710.1	anthrax toxin receptor 2 isoform 3
NM_058172.6	NP_477520.2	anthrax toxin receptor 2 isoform 1 precursor

ANTXR2 Protein Structure

VWA

Anth_Ig

Ant_C

0
100
200
300
400
489 a.a.

Protein Preferred Names

Protein Names

anthrax toxin receptor 2

capillary morphogenesis gene 2 protein

Recombinant ANTXR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76151	CMG-2/ANTXR2 Protein, Human (HEK293, Fc)	P58335-4 (M1-N317)	≥95%
HY-P700656	CMG-2/ANTXR2 Protein, Human (HEK293, His)	NP_477520.2 (Q34-G318)	≥95%

Related Diseases

Diseases

Alias

Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis	Inherited Systemic Hyalinosis
Puretic Syndrome	Infantile Systemic Hyalinosis
HFS	Hyalinosis, Systemic
Systemic Hyalinosis	Molluscum Fibrosum
Murray Syndrome	Murray-Puretic-Drescher Syndrome
Ish	Jhf
Fibromatosis, Juvenile Hyaline	Hyalinosis, Systemic Infantile
Fibromatosis, Hyaline Syndrome	Neurofibromatosis 1

Fibromatosis

Gingival Hypertrophy

Hypertrophy Of Gingivae

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Gastrointestinal Anthrax

Oropharyngeal Anthrax

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis	Urbach-Wiethe Disease
Hyalinosis Cutis Et Mucosae	Lipid Proteinosis
Lipoproteinosis	Urbach Wiethe Disease
Lipoglycoproteinosis	Lipoidosis Cutis Et Mucosae
Lipoidproteinosis	Urbach-Wiethe Lipoid Proteinosis
Urbach-Wiethe Syndrome	LIP
Proteinosis Lipoid

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Protein-Losing Enteropathy

Protein-Losing Enteropathies	Enteropathy, Exudative
Exudative Enteropathy	Ple - [Protein-Losing Enteropathy]

Gingival Disease

Gingival Diseases	Gum Disease
Gingival Disorder	Gingivitis And Periodontal Diseases

Stiff Skin Syndrome

SSKS	Stiff Skin

Oculoglandular Tularemia

Gingival Fibromatosis

Hereditary Gingival Fibromatosis	Hereditary Gingival Hyperplasia
Autosomal Dominant Gingival Fibromatosis	Autosomal Dominant Gingival Hyperplasia
Fibromatosis, Gingival, Hereditary	Fibromatosis, Gingival

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00756	ANTXR2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANTXR2	VGNC	VGNC:25962
Rattus norvegicus	ANTXR2	RGD	RGD:1561294
Felis catus	ANTXR2	VGNC	VGNC:59838
Canis familiaris	ANTXR2	VGNC	VGNC:37936
Macaca mulatta	ANTXR2	VGNC	VGNC:69881
Mus musculus	ANTXR2	MGD	MGI:1919164
Others	ANTXR2	NCBI

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