2. Gene
  3. Bak1 - BCL2-antagonist/killer 1 Gene

Bak1 - BCL2-antagonist/killer 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bak; N-Bak; N-BAK1

Gene ID: 12018 | Gene type: protein coding

About Bak1

Chromosome 17: 27,238,784-27,247,983 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 135 orthologues, 10 paralogues and is associated with 3 phenotypes. Broad expression in large intestine adult (RPKM 19.5), duodenum adult (RPKM 17.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in cellular response to UV and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; cellular calcium ion homeostasis; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Is integral component of mitochondrial outer membrane. Part of Bak complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 Products(1)

mRNA Protein Name
NM_007523.3 NP_031549.2 bcl-2 homologous antagonist/killer

Bak1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (26 - 180)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

bcl-2 homologous antagonist/killer

Bcl2 homologous antagonist/killer

apoptosis regulator BAK

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01357 BAK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01358 Bak1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01359 Bak1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bak1 NCBI NCBI:578