2. Gene
  3. Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bim; Bod; bcl2-L-11; 1500006F24Rik

Gene ID: 12125 | Gene type: protein coding

About Bcl2l11

Chromosome 2: 127,967,958-128,004,467 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 84 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues.

Summary

Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 Family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 Products(10)

mRNA Protein Name
NM_001406060.1 NP_001392989.1 bcl-2-like protein 11 isoform 6
NM_009754.3 NP_033884.1 bcl-2-like protein 11 isoform 3
NM_001291016.1 NP_001277945.1 bcl-2-like protein 11 isoform 5
NM_001406061.1 NP_001392990.1 bcl-2-like protein 11 isoform 7
NM_207680.2 NP_997563.1 bcl-2-like protein 11 isoform 1
NM_207681.2 NP_997564.1 bcl-2-like protein 11 isoform 2
NM_001406059.1 NP_001392988.1 bcl-2-like protein 11 isoform 6
NM_001406057.1 NP_001392986.1 bcl-2-like protein 11 isoform 2
NM_001284410.3 NP_001271339.2 bcl-2-like protein 11 isoform 4
NM_001406058.1 NP_001392987.1 bcl-2-like protein 11 isoform 3

Bcl2l11 Protein Structure

Bim_N

Bim_N: pfam06773 (3 - 39)

Bclx_interact

Bclx_interact: pfam08945 (128 - 163)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 11

Bcl2 interacting mediator of cell death

bcl2-interacting mediator of cell death

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153953 Bcl-2-IN-11 Inhibitor / Unkown
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / Unkown
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l11 NCBI NCBI:10018