CNN1 - calponin 1 Gene

Homo sapiens

Also known as SMCC; Sm-Calp; HEL-S-14

Gene ID: 1264 | Gene type: protein coding

About CNN1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,538,851-11,550,323 (from NCBI)

This gene has 10 transcripts (splice variants), 222 orthologues and 5 paralogues. Biased expression in urinary bladder (RPKM 288.3), endometrium (RPKM 280.5) and 11 other tissues.

Summary

Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CNN1 Products(3)

mRNA	Protein	Name
NM_001299.6	NP_001290.2	calponin-1 isoform 1
NM_001308341.2	NP_001295270.1	calponin-1 isoform 2
NM_001308342.2	NP_001295271.1	calponin-1 isoform 2

CNN1 Protein Structure

Calponin

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

calponin-1

basic calponin

Related Diseases

Diseases

Alias

Subareolar Duct Papillomatosis

Adenoma Of The Nipple

Nipple Benign Neoplasm

Tumor Of Nipple

Marfan Syndrome

MFS	Mfs1
Marfan'S Syndrome	Marfan Syndrome Type 1
Marfan Syndrome, Type I	Mass Phenotype
Contractural Arachnodactyly	Mass Syndrome
Octd	Overlap Connective Tissue Disease
Marfanoid Hypermobility Syndrome	Marfan Disease

Osteogenesis Imperfecta, Type Xv

Osteogenesis Imperfecta Type 15	OI15
Osteogenesis Imperfecta Type Xv	Oi, Type Xv
Osteogenesis Imperfecta 15	Oi Type Xv
Oi-Xv

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

Aortic Dissection

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02892	CNN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CNN1	MGD	MGI:104979
Bos taurus	CNN1	VGNC	VGNC:27508
Canis familiaris	CNN1	VGNC	VGNC:57306
Felis catus	CNN1	VGNC	VGNC:61021
Rattus norvegicus	CNN1	RGD	RGD:621883
Macaca mulatta	CNN1	VGNC	VGNC:71277

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