2. Gene
  3. Ccr3 - chemokine (C-C motif) receptor 3 Gene

Ccr3 - chemokine (C-C motif) receptor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CKR3; Cmkbr3; CC-CKR3; Cmkbr1l2

Gene ID: 12771 | Gene type: protein coding

About Ccr3

Chromosome 9: 123,822,009-123,831,726 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 142 orthologues, 25 paralogues and is associated with 22 phenotypes. Biased expression in spleen adult (RPKM 2.4), subcutaneous fat pad adult (RPKM .5) and 4 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Acts upstream of or within chemotaxis. Predicted to be located in endosome; extracellular space; and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccr3 Products(1)

mRNA Protein Name
NM_009914.4 NP_034044.3 probable C-C chemokine receptor type 3

Ccr3 Protein Structure

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 65)

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 315)

7tmA_CCR3

7tmA_CCR3: cd15185 (72 - 97)

7tmA_CCR3

7tmA_CCR3: cd15185 (109 - 139)

7tmA_CCR3

7tmA_CCR3: cd15185 (151 - 173)

7tmA_CCR3

7tmA_CCR3: cd15185 (199 - 228)

7tmA_CCR3

7tmA_CCR3: cd15185 (235 - 265)

7tmA_CCR3

7tmA_CCR3: cd15185 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

probable C-C chemokine receptor type 3

C-C CKR-3

CC chemokine receptor 3

CC-CKR-3

CCR-3

MIP-1 alpha RL2

MIP-1 alphaRL2

chemokine (C-C) receptor 1,-like 2

chemokine (C-C) receptor 3

macrophage inflammatory protein 1-alpha receptor-like 2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136788 ALK4290 Inhibitor 99.21% Phase 2
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107051 GW 766994 Antagonist 98.77% Unkown
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-103363 SB-328437 Antagonist 98.48% Unkown
HY-P3982 CKLF1-C19 Chemical 99.95% Unkown
HY-U00331 CCR3 antagonist 1 Antagonist 98.95% Unkown
HY-120629 BMS-639623 Antagonist / Unkown
HY-N10397 Maceneolignan H Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr3 NCBI NCBI:1232