Ccr7 - chemokine (C-C motif) receptor 7 Gene

Mus musculus

Also known as EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7

Gene ID: 12775 | Gene type: protein coding

About Ccr7

Chromosome 11: 99,035,022-99,045,903 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 197 orthologues, 25 paralogues and is associated with 48 phenotypes. Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 7.1) and 2 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Acts upstream of or within chemotaxis; homeostasis of number of cells; and immune response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and white fat. Used to study Sjogren's syndrome. Orthologous to human CCR7 (C-C motif Chemokine Receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Ccr7 Products(2)

mRNA	Protein	Name
NM_001301713.1	NP_001288642.1	C-C chemokine receptor type 7 isoform b
NM_007719.2	NP_031745.2	C-C chemokine receptor type 7 isoform a precursor

Ccr7 Protein Structure

7tm_GPCRs

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 7

EBV-induced G-protein coupled receptor 1	MIP-3 beta receptor
chemokine (C-C) receptor 7	epstein-Barr virus-induced G-protein coupled receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112701	CCR6 inhibitor 1	Inhibitor	99.60%	Unkown
HY-133073	CCR7 Ligand 1	Antagonist	99.62%	Unkown
HY-120427	Cosalane	Inhibitor	/	Unkown
HY-120427	Cosalane	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr7	NCBI	NCBI:1236

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