2. Gene
  3. Ackr3 - atypical chemokine receptor 3 Gene

Ackr3 - atypical chemokine receptor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1

Gene ID: 12778 | Gene type: protein coding

About Ackr3

Chromosome 1: 90,131,702-90,144,473 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 252 orthologues, 25 paralogues and is associated with 49 phenotypes. Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 2 other tissues.

Summary

Predicted to enable chemokine binding activity; Chemokine Receptor activity; and scavenger receptor activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ackr3 Products(2)

mRNA Protein Name
NM_007722.4 NP_031748.2 atypical chemokine receptor 3
NM_001271607.1 NP_001258536.1 atypical chemokine receptor 3

Ackr3 Protein Structure

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (44 - 325)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (45 - 71)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (78 - 102)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (116 - 146)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (159 - 180)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (208 - 235)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (244 - 274)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (293 - 318)

  • 0
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  • 362 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 3

C-X-C chemokine receptor type 7

G-protein coupled receptor RDC1 homolog

chemokine (C-X-C motif) receptor 7

chemokine orphan receptor 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123813 CCX-777 Agonist 98.73% Unkown
HY-161414 trans-VUF25471 / Unkown
HY-D2201 Fluorescent ACKR3 antagonist 1 / Unkown
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ackr3 NCBI NCBI:57007