IQGAP3 - IQ motif containing GTPase activating protein 3 Gene

Homo sapiens

Gene ID: 128239 | Gene type: protein coding

About IQGAP3

This gene has 4 transcripts (splice variants), 213 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues.

Summary

Enables Calmodulin binding activity and Myosin VI LIGHT chain binding activity. Predicted to be involved in regulation of actin Cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IQGAP3 Products(1)

mRNA	Protein	Name
NM_178229.5	NP_839943.3	ras GTPase-activating-like protein IQGAP3

IQGAP3 Protein Structure

RasGAP

RasGAP_C

0
300
600
900
1200
1500
1631 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating-like protein IQGAP3

Related Diseases

Diseases

Alias

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06887	IQGAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IQGAP3	VGNC	VGNC:53495
Bos taurus	IQGAP3	VGNC	VGNC:30260
Rattus norvegicus	IQGAP3	RGD	RGD:1305951
Felis catus	IQGAP3	VGNC	VGNC:62966
Macaca mulatta	IQGAP3	VGNC	VGNC:73634
Mus musculus	IQGAP3	MGD	MGI:3028642

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