DRAM2 - DNA damage regulated autophagy modulator 2 Gene

Homo sapiens

Also known as CORD21; PRO180; TMEM77; WWFQ154

Gene ID: 128338 | Gene type: protein coding

About DRAM2

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:111,117,163-111,140,093 (from NCBI)

This gene has 10 transcripts (splice variants), 224 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 29.0), spleen (RPKM 26.6) and 25 other tissues.

Summary

The protein encoded by this gene binds microtubule-associated protein 1 LIGHT chain 3 and is required for Autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two MicroRNAs (MicroRNA 125b-1 and MicroRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]

DRAM2 Products(13)

mRNA	Protein	Name
NM_001349881.2	NP_001336810.1	DNA damage-regulated autophagy modulator protein 2 isoform a
NM_001349882.2	NP_001336811.1	DNA damage-regulated autophagy modulator protein 2 isoform a
NM_001349884.2	NP_001336813.1	DNA damage-regulated autophagy modulator protein 2 isoform a
NM_001349885.2	NP_001336814.1	DNA damage-regulated autophagy modulator protein 2 isoform a
NM_001349886.2	NP_001336815.1	DNA damage-regulated autophagy modulator protein 2 isoform b
NM_001349887.2	NP_001336816.1	DNA damage-regulated autophagy modulator protein 2 isoform b
NM_001349888.2	NP_001336817.1	DNA damage-regulated autophagy modulator protein 2 isoform b
NM_001349889.2	NP_001336818.1	DNA damage-regulated autophagy modulator protein 2 isoform c
NM_001349890.2	NP_001336819.1	DNA damage-regulated autophagy modulator protein 2 isoform c
NM_001349891.2	NP_001336820.1	DNA damage-regulated autophagy modulator protein 2 isoform c
NM_001349892.2	NP_001336821.1	DNA damage-regulated autophagy modulator protein 2 isoform c
NM_001349893.2	NP_001336822.1	DNA damage-regulated autophagy modulator protein 2 isoform c
NM_178454.6	NP_848549.3	DNA damage-regulated autophagy modulator protein 2 isoform a

DRAM2 Protein Structure

Frag1

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

DNA damage-regulated autophagy modulator protein 2

damage regulated autophagy modulator 2

Related Diseases

Diseases

Alias

Cone-Rod Dystrophy 21

CORD21	Retinal Dystrophy With Early Macular Involvement
Dystrophy, Cone-Rod, Type 21

Cone-Rod Dystrophy 16

Retinitis Pigmentosa 64	Retinal Dystrophy With Early Macular Involvement
CORD16	RP64

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03988	DRAM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DRAM2	VGNC	VGNC:61620
Mus musculus	DRAM2	MGD	MGI:1914421
Canis familiaris	DRAM2	VGNC	VGNC:40089
Macaca mulatta	DRAM2	VGNC	VGNC:71916
Rattus norvegicus	DRAM2	RGD	RGD:1564099
Bos taurus	DRAM2	VGNC	VGNC:28202

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