PLEKHH2 - pleckstrin homology, MyTH4 and FERM domain containing H2 Gene

Homo sapiens

Also known as PLEKHH1L

Gene ID: 130271 | Gene type: protein coding

About PLEKHH2

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,637,260-43,767,987 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in lung (RPKM 15.4), endometrium (RPKM 10.8) and 21 other tissues.

Summary

Predicted to enable actin binding activity. Predicted to be involved in negative regulation of actin filament depolymerization. Located in several cellular components, including cytosol; lamellipodium; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHH2 Products(1)

mRNA	Protein	Name
NM_172069.4	NP_742066.2	pleckstrin homology domain-containing family H member 2

PLEKHH2 Protein Structure

MyTH4

FERM_M

0
300
600
900
1200
1493 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family H member 2

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

Related Diseases

Diseases

Alias

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10696	PLEKHH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLEKHH2	VGNC	VGNC:44683
Felis catus	PLEKHH2	VGNC	VGNC:64234
Bos taurus	PLEKHH2	VGNC	VGNC:33021
Macaca mulatta	PLEKHH2	VGNC	VGNC:76146
Mus musculus	PLEKHH2	MGD	MGI:2146813
Rattus norvegicus	PLEKHH2	RGD	RGD:1304935

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