2. Gene
  3. Ctsk - cathepsin K Gene

Ctsk - cathepsin K Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as catK; Ms10q; MMS10-Q

Gene ID: 13038 | Gene type: protein coding

About Ctsk

Chromosome 3: 95,406,567-95,416,673 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 240 orthologues, 24 paralogues and is associated with 55 phenotypes. Biased expression in bladder adult (RPKM 27.4), limb E14.5 (RPKM 13.7) and 12 other tissues.

Summary

This gene encodes a member of the Cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional Enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]

Ctsk Products(1)

mRNA Protein Name
NM_007802.4 NP_031828.2 cathepsin K preproprotein

Ctsk Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (25 - 84)

Peptidase_C1

Peptidase_C1: pfam00112 (114 - 326)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

cathepsin K

Cat K

Recombinant Ctsk Proteins

Cat. No. Product Name Accession Purity
HY-P72157 Cathepsin K Protein, Mouse (His) P55097 (V115-M329) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143714 Cathepsin K inhibitor 2 Inhibitor / Unkown
HY-155960 SH491 / Unkown
HY-RS03337 CTSK Human Pre-designed siRNA Set A / Unkown
HY-RS03338 Ctsk Mouse Pre-designed siRNA Set A / Unkown
HY-RS03339 Ctsk Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsk NCBI NCBI:1513
Rattus norvegicus Ctsk NCBI NCBI:29175