COPA - COPI coat complex subunit alpha Gene

Homo sapiens

Also known as AILJK; HEP-COP; alpha-COP

Gene ID: 1314 | Gene type: protein coding

About COPA

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,288,594-160,343,250 (from NCBI)

This gene has 35 transcripts (splice variants), 217 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 39.8), colon (RPKM 29.3) and 25 other tissues.

Summary

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 Amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

COPA Products(2)

mRNA	Protein	Name
NM_001098398.2	NP_001091868.1	coatomer subunit alpha isoform 1
NM_004371.4	NP_004362.2	coatomer subunit alpha isoform 2

COPA Protein Structure

WD40

Coatomer_WDAD

COPI_C

0
200
400
600
800
1000
1224 a.a.

Protein Preferred Names

Protein Names

coatomer subunit alpha

alpha coat protein

Related Diseases

Diseases

Alias

Autoimmune Interstitial Lung, Joint, And Kidney Disease

Autoimmune Interstitial Lung Disease-Arthritis Syndrome	AILJK
Copa Syndrome

Parainfluenza Virus Type 3

Human Parainfluenza Virus Type 3

Piv3

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Lipid Pneumonia

Exogenous Lipoid Pneumonia	Lipoid Pneumonitis
Pneumonia, Lipid	Pneumonia Lipid
Lipoid Pneumonia

Familial Cold Autoinflammatory Syndrome 3

Plaid	Familial Atypical Cold Urticaria
Facu	FCAS3
Antibody Deficiency And Immune Dysregulation, Plcg2-Associated	Plcg2-Associated Antibody Deficiency And Immune Dysregulation
Familial Cold Urticaria With Common Variable Immunodeficiency	Plcg2 Associated Antibody Deficiency And Immune Dysregulation
Antibody Deficiency And Immune Dysregulation Placg2-Associated	Autoinflammatory Syndrome, Cold, Familial, Type 3

Ventilation Pneumonitis

Air-Conditioner And Humidifier Lung	Humidifier Lung
Air Conditioner Lung	Air Humidifier Pneumonitis
Sauna Takers Lung	Air Conditioner Pneumonitis
Humidifier Pneumonitis	Air Humidifier Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03021	COPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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