2. Gene
  3. ATF6B - activating transcription factor 6 beta Gene

ATF6B - activating transcription factor 6 beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as G13; CREBL1; CREB-RP

Gene ID: 1388 | Gene type: protein coding

About ATF6B

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,115,264-32,128,246 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 189 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 32.2), skin (RPKM 32.1) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ATF6B Products(2)

mRNA Protein Name
NM_001136153.2 NP_001129625.1 cyclic AMP-dependent transcription factor ATF-6 beta isoform b
NM_004381.5 NP_004372.3 cyclic AMP-dependent transcription factor ATF-6 beta isoform a

ATF6B Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (321 - 382)

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Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-6 beta

Creb-related protein

Related Diseases

Diseases Alias
Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01135 ATF6B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ATF6B VGNC VGNC:81026
Mus musculus ATF6B MGD MGI:105121
Bos taurus ATF6B VGNC VGNC:26245
Rattus norvegicus ATF6B RGD RGD:1303317
Felis catus ATF6B VGNC VGNC:59993
Canis familiaris ATF6B VGNC VGNC:52104