CRHR2 - corticotropin releasing hormone receptor 2 Gene

Homo sapiens

Also known as CRF2; CRFR2; CRF-RB; HM-CRF

Gene ID: 1395 | Gene type: protein coding

About CRHR2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,651,942-30,700,103 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues and 42 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related Peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

CRHR2 Products(7)

mRNA	Protein	Name
NM_001202482.2	NP_001189411.1	corticotropin-releasing factor receptor 2 isoform 4
XM_047419893.1	XP_047275849.1	corticotropin-releasing factor receptor 2 isoform X2
NM_001202475.1	NP_001189404.1	corticotropin-releasing factor receptor 2 isoform 2 precursor
NM_001202481.1	NP_001189410.1	corticotropin-releasing factor receptor 2 isoform 3
XM_047419892.1	XP_047275848.1	corticotropin-releasing factor receptor 2 isoform X1
NM_001883.5	NP_001874.2	corticotropin-releasing factor receptor 2 isoform 1
NM_001202483.2	NP_001189412.1	corticotropin-releasing factor receptor 2 isoform 5

CRHR2 Protein Structure

HRM

7tm_2

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

corticotropin-releasing factor receptor 2

CRH-R2

Related Diseases

Diseases

Alias

Borderline Personality Disorder

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Generalized Anxiety Disorder

Anxiety Generalized

Colitis

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Substance Dependence

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3684A	[DPro5] Corticotropin Releasing Factor, human, rat TFA	Agonist	99.71%	Unkown
HY-RS03171	CRHR2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS03172	Crhr2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03173	Crhr2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRHR2	VGNC	VGNC:27709
Macaca mulatta	CRHR2	VGNC	VGNC:71492
Canis familiaris	CRHR2	VGNC	VGNC:39611
Rattus norvegicus	CRHR2	RGD	RGD:70547
Mus musculus	CRHR2	MGD	MGI:894312
Felis catus	CRHR2	VGNC	VGNC:78430

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