2. Gene
  3. GAB3 - GRB2 associated binding protein 3 Gene

GAB3 - GRB2 associated binding protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 139716 | Gene type: protein coding

About GAB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,675,249-154,751,566 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in spleen (RPKM 7.6), bone marrow (RPKM 4.4) and 22 other tissues.

Summary

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine Phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GAB3 Products(3)

mRNA Protein Name
NM_001081573.3 NP_001075042.1 GRB2-associated-binding protein 3 isoform 1
NM_001282283.2 NP_001269212.1 GRB2-associated-binding protein 3 isoform 3
NM_080612.4 NP_542179.1 GRB2-associated-binding protein 3 isoform 2

GAB3 Protein Structure

PH

PH: PH domain (8 - 116)

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  • 586 a.a.
Protein Preferred Names Protein Names

GRB2-associated-binding protein 3

DOS/Gab family member 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05199 GAB3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GAB3 VGNC VGNC:72736
Bos taurus GAB3 VGNC VGNC:29184
Felis catus GAB3 VGNC VGNC:62413
Mus musculus GAB3 MGD MGI:2387324
Canis familiaris GAB3 VGNC VGNC:54143