ADORA3 - adenosine A3 receptor Gene

Homo sapiens

Also known as A3AR

Gene ID: 140 | Gene type: protein coding

About ADORA3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,499,429-111,503,633 (from NCBI)

This gene has 4 transcripts (splice variants), 272 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues.

Summary

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

ADORA3 Products(3)

mRNA	Protein	Name
NM_000677.4	NP_000668.1	adenosine receptor A3 isoform A
NM_001302678.2	NP_001289607.1	adenosine receptor A3 isoform B
NM_001302679.2	NP_001289608.1	adenosine receptor A3 isoform C

ADORA3 Protein Structure

7tm_1

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A3

Related Diseases

Diseases

Alias

Exfoliation Syndrome

Pseudoexfoliation Glaucoma	Pseudoexfoliation Syndrome
Exfoliation Syndrome, Susceptibility To	XFS
Exfoliation Glaucoma	Xfg
Pseudoexfoliation Of The Lens	Pexg
Pexs	Exfoliative Syndrome
Glaucoma Capsulare	Pex
Pseudo-Exfoliation Syndrome

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Ischemia

Acute Coronary Syndrome

Myocardial Stunning

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Subacute Leukemia

Vasculogenic Impotence

Impotence, Vasculogenic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00400	ADORA3 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00401	Adora3 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00402	ADORA3 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADORA3	VGNC	VGNC:54876
Mus musculus	ADORA3	MGD	MGI:104847
Canis familiaris	ADORA3	VGNC	VGNC:37668
Rattus norvegicus	ADORA3	RGD	RGD:2051
Felis catus	ADORA3	VGNC	VGNC:59650

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