SUN5 - Sad1 and UNC84 domain containing 5 Gene

Homo sapiens

Also known as SPAG4L; SPGF16; TSARG4; dJ726C3.1

Gene ID: 140732 | Gene type: protein coding

About SUN5

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,983,775-33,004,433 (from NCBI)

This gene has 4 transcripts (splice variants), 137 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 7.9).

Summary

The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]

SUN5 Products(1)

mRNA	Protein	Name
NM_080675.4	NP_542406.2	SUN domain-containing protein 5

SUN5 Protein Structure

Sad1_UNC

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

SUN domain-containing protein 5

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Spermatogenic Failure 16

SPGF16	Acephalic Spermatozoa Syndrome
Spermatozoa, Acephalic

Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Infertility

Spermatogenic Failure 14

SPGF14

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14032	SUN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUN5	RGD	RGD:1306357
Canis familiaris	SUN5	VGNC	VGNC:46987
Bos taurus	SUN5	VGNC	VGNC:35476
Felis catus	SUN5	VGNC	VGNC:65844
Mus musculus	SUN5	MGD	MGI:1923657
Macaca mulatta	SUN5	VGNC	VGNC:78133

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