2. Gene
  3. Pde11a - phosphodiesterase 11A Gene

Pde11a - phosphodiesterase 11A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 140928 | Gene type: protein coding

About Pde11a

Primary_assembly 3: 60,913,562-61,297,158 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 101 orthologues, 20 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 28.2), Kidney (RPKM 22.) and 5 other tissues.

Summary

Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2022]

Pde11a Products(3)

mRNA Protein Name
NM_001127480.2 NP_001120952.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 3
NM_080893.2 NP_543169.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 4
NM_001127481.3 NP_001120953.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 2

Pde11a Protein Structure

GAF

GAF: smart00065 (216 - 379)

GAF

GAF: smart00065 (401 - 567)

PDEase_I

PDEase_I: pfam00233 (662 - 897)

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  • 935 a.a.
Protein Preferred Names Protein Names

dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

cAMP and cGMP phosphodiesterase 11A

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156434 PDE11A4-IN-1 Inhibitor / Unkown
HY-RS10202 PDE11A Human Pre-designed siRNA Set A / Unkown
HY-RS10203 Pde11a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10204 Pde11a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde11a NCBI NCBI:50940