2. Gene
  3. ASB14 - ankyrin repeat and SOCS box containing 14 Gene

ASB14 - ankyrin repeat and SOCS box containing 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 142686 | Gene type: protein coding

About ASB14

This gene has 3 transcripts (splice variants), 264 orthologues and 7 paralogues. Ubiquitous expression in heart (RPKM 1.8), bone marrow (RPKM 1.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]

ASB14 Products(2)

mRNA Protein Name
NM_001142733.3 NP_001136205.2 ankyrin repeat and SOCS box protein 14 isoform 1
NM_130387.5 NP_569058.1 ankyrin repeat and SOCS box protein 14 isoform 2 precursor

ASB14 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (70 - 148)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (151 - 211)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (223 - 302)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (319 - 414)

SOCS_box

SOCS_box: SOCS box (531 - 573)

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  • 587 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and SOCS box protein 14

ankyrin repeat domain-containing SOCS box protein Asb-14

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01063 ASB14 Human Pre-designed siRNA Set A / Unkown
HY-136962 ASB-14 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASB14 RGD RGD:1596812
Bos taurus ASB14 VGNC VGNC:26191
Felis catus ASB14 VGNC VGNC:69351
Mus musculus ASB14 MGD MGI:2655107
Macaca mulatta ASB14 VGNC VGNC:84237
Canis familiaris ASB14 VGNC VGNC:38158