ISM2 - isthmin 2 Gene

Homo sapiens

Also known as TAIL1; THSD3

Gene ID: 145501 | Gene type: protein coding

About ISM2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,474,394-77,498,816 (from NCBI)

This gene has 8 transcripts (splice variants) and 56 orthologues. Restricted expression toward placenta (RPKM 113.4).

Summary

The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]

ISM2 Products(2)

mRNA	Protein	Name
NM_182509.4	NP_872315.2	isthmin-2 isoform 3 precursor
NM_199296.3	NP_954993.1	isthmin-2 isoform 1 precursor

ISM2 Protein Structure

TSP_1

AMOP

0
100
200
300
400
500
571 a.a.

Protein Preferred Names

Protein Names

isthmin-2

isthmin 2 homolog

Related Diseases

Diseases

Alias

Indolent Systemic Mastocytosis

Ism

Placental Site Trophoblastic Tumor

Trophoblastic Tumor Placental Site	Trophoblastic Tumor, Placental Site
Placental Site Trophoblastic Tumour	Placental-Site Gestational Trophoblastic Neoplasm
Placenta Neoplasm	Psst
Deciduoma	Placental Cancer
Primary Malignant Neoplasm Of Placenta

Arrhythmogenic Right Ventricular Dysplasia, Familial, 9

Arrhythmogenic Right Ventricular Dysplasia 9	ARVD9
Arrhythmogenic Right Ventricular Cardiomyopathy 9	Arvc9
Familial Arrhythmogenic Right Ventricular Dysplasia 9	Dysplasia, Arrhythmogenic Right Ventricular, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06936	ISM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ISM2	VGNC	VGNC:73642
Felis catus	ISM2	VGNC	VGNC:62977
Mus musculus	ISM2	MGD	MGI:2685110
Rattus norvegicus	ISM2	RGD	RGD:1589343
Bos taurus	ISM2	VGNC	VGNC:55117

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