2. Gene
  3. Gnrhr - gonadotropin releasing hormone receptor Gene

Gnrhr - gonadotropin releasing hormone receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14715 | Gene type: protein coding

About Gnrhr

Chromosome 5: 86,328,613-86,345,760 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 241 orthologues, 16 paralogues and is associated with 65 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable gonadotropin-releasing hormone receptor activity; growth hormone-releasing hormone receptor activity; and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell population proliferation. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gnrhr Products(3)

mRNA Protein Name
NM_001310651.1 NP_001297580.1 gonadotropin-releasing hormone receptor isoform 2
NM_010323.2 NP_034453.1 gonadotropin-releasing hormone receptor isoform 1
NM_001310653.1 NP_001297582.1 gonadotropin-releasing hormone receptor isoform 3

Gnrhr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (35 - 326)

7tm_GPCRs

7tm_GPCRs: cd14964 (37 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (76 - 99)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (157 - 173)

7tm_GPCRs

7tm_GPCRs: cd14964 (207 - 230)

7tm_GPCRs

7tm_GPCRs: cd14964 (264 - 286)

7tm_GPCRs

7tm_GPCRs: cd14964 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

gonadotropin-releasing hormone receptor

gnRH receptor

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16168A Degarelix 99.92% Unkown
HY-14369 Elagolix sodium Antagonist 99.94% Unkown
HY-16168B Degarelix acetate hydrate / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14789 (R)-Elagolix Antagonist 96.22% Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W041308 DCOIT Agonist 99.74% Unkown
HY-151247 GnRH-R antagonist 1 Antagonist / Unkown
HY-133080 BAY-784 Antagonist / Unkown
HY-14369S Elagolix-13C,d3 sodium Antagonist / Unkown
HY-16168AS Degarelix-d7 Antagonist / Unkown
HY-RS05578 GNRHR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05579 Gnrhr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05580 Gnrhr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnrhr NCBI NCBI:2798
Macaca mulatta Gnrhr NCBI NCBI:711577