2. Gene
  3. S1pr2 - sphingosine-1-phosphate receptor 2 Gene

S1pr2 - sphingosine-1-phosphate receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik

Gene ID: 14739 | Gene type: protein coding

About S1pr2

Chromosome 9: 20,873,657-20,888,077 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 56 phenotypes. Broad expression in lung adult (RPKM 19.6), limb E14.5 (RPKM 17.) and 24 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 Products(1)

mRNA Protein Name
NM_010333.4 NP_034463.2 sphingosine 1-phosphate receptor 2

S1pr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (34 - 298)

7tm_GPCRs

7tm_GPCRs: cd14964 (35 - 59)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (149 - 165)

7tm_GPCRs

7tm_GPCRs: cd14964 (186 - 209)

7tm_GPCRs

7tm_GPCRs: cd14964 (231 - 253)

7tm_GPCRs

7tm_GPCRs: cd14964 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 2

G-protein coupled receptor 13

S1P receptor 2

S1P receptor Edg-5

endothelial differentiation G-protein coupled receptor 5

endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

lysophospholipid receptor B2

sphingosine 1-phosphate receptor Edg-5

sphingosine-1-phosphate receptor S1P(2)

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 98.88% Yes
HY-12355A Siponimod hemifumarate Agonist / Unkown
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139310 GLPG2938 Antagonist 99.93% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr2 NCBI NCBI:9294
Rattus norvegicus S1pr2 NCBI NCBI:29415