2. Gene
  3. CSTF1 - cleavage stimulation factor subunit 1 Gene

CSTF1 - cleavage stimulation factor subunit 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CstF-50; CstFp50

Gene ID: 1477 | Gene type: protein coding

About CSTF1

Cytogenetic location: 20q13.2-q13.31 Genomic coordinates (GRCh38): 20:56,392,379-56,406,362 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

CSTF1 Products(3)

mRNA Protein Name
NM_001033521.2 NP_001028693.1 cleavage stimulation factor subunit 1
NM_001033522.2 NP_001028694.1 cleavage stimulation factor subunit 1
NM_001324.3 NP_001315.1 cleavage stimulation factor subunit 1

CSTF1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (105 - 134)

WD40

WD40: WD domain, G-beta repeat (166 - 201)

WD40

WD40: WD domain, G-beta repeat (261 - 290)

WD40

WD40: WD domain, G-beta repeat (308 - 334)

WD40

WD40: WD domain, G-beta repeat (395 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

cleavage stimulation factor subunit 1

CF-1 50 kDa subunit

Related Diseases

Diseases Alias
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03273 CSTF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CSTF1 VGNC VGNC:71535
Felis catus CSTF1 VGNC VGNC:61239
Bos taurus CSTF1 VGNC VGNC:27780
Rattus norvegicus CSTF1 RGD RGD:1309267
Mus musculus CSTF1 MGD MGI:1914587
Canis familiaris CSTF1 VGNC VGNC:39682