CREB3L4 - cAMP responsive element binding protein 3 like 4 Gene

Homo sapiens

Also known as JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP

Gene ID: 148327 | Gene type: protein coding

About CREB3L4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,967,487-153,974,359 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues and 9 paralogues. Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues.

Summary

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CREB3L4 Products(5)

mRNA	Protein	Name
NM_001255978.2	NP_001242907.1	cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NM_001255979.2	NP_001242908.1	cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NM_001255980.2	NP_001242909.1	cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2
NM_001255981.2	NP_001242910.1	cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2
NM_130898.4	NP_570968.1	cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

CREB3L4 Protein Structure

bZIP_1

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 4

CREB-4

Related Diseases

Diseases

Alias

Nemaline Myopathy 1

Cap Myopathy 1	NEM1
Nemaline Myopathy 1, Autosomal Dominant Or Recessive	Nemaline Myopathy, Type 1
CAPM1	Cap Disease
Cap Myopathy Tpm3-Related	Nemaline Myopathy 1 Autosomal Dominant Or Recessive
Myopathy, Nemaline, Type 1	Cap Myopathy

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03153	CREB3L4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CREB3L4	RGD	RGD:1359278
Canis familiaris	CREB3L4	VGNC	VGNC:39599
Macaca mulatta	CREB3L4	VGNC	VGNC:71437
Mus musculus	CREB3L4	MGD	MGI:1916603
Felis catus	CREB3L4	VGNC	VGNC:61169
Bos taurus	CREB3L4	VGNC	VGNC:27697

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