SAMD11 - sterile alpha motif domain containing 11 Gene

Homo sapiens

Also known as MRS

Gene ID: 148398 | Gene type: protein coding

About SAMD11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:923,923-944,574 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 7.4), endometrium (RPKM 5.9) and 25 other tissues.

Summary

Predicted to enable several functions, including histone binding activity; protein domain specific binding activity; and protein self-association. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SAMD11 Products(3)

mRNA	Protein	Name
NM_001385640.1	NP_001372569.1	sterile alpha motif domain-containing protein 11 isoform 2
NM_001385641.1	NP_001372570.1	sterile alpha motif domain-containing protein 11 isoform 1
NM_152486.4	NP_689699.3	sterile alpha motif domain-containing protein 11 isoform 3

SAMD11 Protein Structure

SAM_2

0
200
400
600
681 a.a.

Protein Preferred Names

Protein Names

sterile alpha motif domain-containing protein 11

SAM domain-containing protein 11

Related Diseases

Diseases

Alias

Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12423	SAMD11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SAMD11	VGNC	VGNC:45849
Bos taurus	SAMD11	VGNC	VGNC:59361
Felis catus	SAMD11	VGNC	VGNC:64861
Rattus norvegicus	SAMD11	RGD	RGD:1310271
Mus musculus	SAMD11	MGD	MGI:2446220

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