EXOC8 - exocyst complex component 8 Gene

Homo sapiens

Also known as EXO84; SEC84; Exo84p; NEDMISB

Gene ID: 149371 | Gene type: protein coding

About EXOC8

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:231,332,753-231,337,852 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and is associated with 1 phenotype.

Summary

This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

EXOC8 Products(1)

mRNA	Protein	Name
NM_175876.5	NP_787072.2	exocyst complex component 8

EXOC8 Protein Structure

Vps51

0
200
400
600
721 a.a.

Protein Preferred Names

Protein Names

exocyst complex component 8

exocyst complex 84 kDa subunit

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Microcephaly, Seizures, And Brain Atrophy

NEDMISB

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04594	EXOC8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EXOC8	VGNC	VGNC:72330
Mus musculus	EXOC8	MGD	MGI:2142527
Felis catus	EXOC8	VGNC	VGNC:62005
Bos taurus	EXOC8	VGNC	VGNC:28653
Canis familiaris	EXOC8	VGNC	VGNC:40519
Rattus norvegicus	EXOC8	RGD	RGD:620245

Name
Email *

	Sorry, but the email address you supplied was invalid.