SMYD1 - SET and MYND domain containing 1 Gene

Homo sapiens

Also known as BOP; KMT3D; ZMYND18; ZMYND22

Gene ID: 150572 | Gene type: protein coding

About SMYD1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,067,825-88,113,384 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 5 paralogues. Restricted expression toward heart (RPKM 63.9).

Summary

Predicted to enable histone-lysine N-methyltransferase activity. Involved in positive regulation of myoblast differentiation and positive regulation of myotube differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SMYD1 Products(2)

mRNA	Protein	Name
NM_001330364.2	NP_001317293.1	histone-lysine N-methyltransferase SMYD1 isoform 2
NM_198274.4	NP_938015.1	histone-lysine N-methyltransferase SMYD1 isoform 1

SMYD1 Protein Structure

SET

zf-MYND

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase SMYD1

CD8 beta opposite

Related Diseases

Diseases

Alias

Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat

Epiphyseal Dysplasia, Multiple, 1

EDM1	Multiple Epiphyseal Dysplasia 1
Multiple Epiphyseal Dysplasia Type 1	Med1
Multiple Epiphyseal Dysplasia Comp-Related	Polyepiphyseal Dysplasia Type 1
Multiple Epiphyseal Dysplasia, Comp-Related	Epiphyseal Dysplasia Multiple 1
Epiphyseal Dysplasia, Multiple 1	Dysplasia, Epiphyseal, Multiple, Type 1

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13461	SMYD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SMYD1	VGNC	VGNC:46581
Bos taurus	SMYD1	VGNC	VGNC:35042
Macaca mulatta	SMYD1	VGNC	VGNC:77751
Rattus norvegicus	SMYD1	RGD	RGD:1305105
Felis catus	SMYD1	VGNC	VGNC:81223
Mus musculus	SMYD1	MGD	MGI:104790

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