2. Gene
  3. SHISA3 - shisa family member 3 Gene

SHISA3 - shisa family member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as hShisa3

Gene ID: 152573 | Gene type: protein coding

About SHISA3

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:42,397,488-42,402,487 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 5 paralogues. Biased expression in kidney (RPKM 14.3), lymph node (RPKM 4.2) and 12 other tissues.

Summary

This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both Wnt and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

SHISA3 Products(1)

mRNA Protein Name
NM_001080505.3 NP_001073974.1 protein shisa-3 homolog precursor

SHISA3 Protein Structure

Shisa

Shisa: Wnt and FGF inhibitory regulator (23 - 196)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

protein shisa-3 homolog

shisa homolog 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12867 SHISA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SHISA3 VGNC VGNC:34599
Rattus norvegicus SHISA3 RGD RGD:1565710
Mus musculus SHISA3 MGD MGI:3041225
Felis catus SHISA3 VGNC VGNC:107465
Macaca mulatta SHISA3 VGNC VGNC:107197