CYP3A7 - cytochrome P450 family 3 subfamily A member 7 Gene

Homo sapiens

Also known as CP37; CYPIIIA7; P450HLp2; P450-HFLA; P-450111A7; P-450(HFL33)

Gene ID: 1551 | Gene type: protein coding

About CYP3A7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,705,036-99,735,196 (from NCBI)

This gene has 4 transcripts (splice variants), 678 orthologues and 3 paralogues. Biased expression in liver (RPKM 26.8), gall bladder (RPKM 5.5) and 4 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of Cholesterol, Steroids and other lipids. This Enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

CYP3A7 Products(1)

mRNA	Protein	Name
NM_000765.5	NP_000756.3	cytochrome P450 3A7

CYP3A7 Protein Structure

p450

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 3A7

aryl hydrocarbon hydroxylase

Related Diseases

Diseases

Alias

Myopathy, Centronuclear, 4

CNM4	Centronuclear Myopathy 4
Congenital Myopathy With Internal Nuclei And Atypical Cores	Centronuclear Myopathy Type 4
Myopathy, Centronuclear, Type 4

Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn

Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome	Crigler-Najjar Syndrome Type 1
Bilirubin Udp Glucuronyl Transferase Deficiency	Crigler Najjar Syndrome
Crigler Najjar Syndrome, Type 1	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency
Bilirubin-Ugt Deficiency	Hyperbilirubinemia, Crigler-Najjar Type I
Hblrcn1	Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Hereditary Unconjugated Hyperbilirubinemia	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1
Bilirubin-Ugt Deficiency Type 1	Crigler-Najjar Syndrome 1
CN1	Cn-I
Crigler-Najjar Syndrome Type I	Hereditary Unconjugated Hyperbilirubinaemia
Ugt Deficiency	Bilirubin Glucuronosyltransferase Deficiency
Crigler-Najjar Disease Or Syndrome	Deficiency Of Glucuronosyltransferase
Glucuronyl Transferase Deficiency	Glucuronyltransferase Deficiency
Udp Glucuronyl Transferase Deficiency	Cns - [Crigler-Najjar Syndrome]
Congenital Familial Nonhemolytic Jaundice

Dystonia 11, Myoclonic

Myoclonic Dystonia	Myoclonus-Dystonia Syndrome
DYT11	Myoclonic Dystonia 11
Alcohol-Responsive Dystonia	Myoclonus, Hereditary Essential
Dystonia-11, Myoclonic	Myoclonus-Dystonia
Dystonia 11	Hereditary Essential Myoclonus
Dystonia, Alcohol-Responsive	Dyt-Sgce
Dystonia, Alcohol Responsive	Dystonia-11
Dystonia, Myoclonic	Dystonia, Myoclonic, Type 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18642	CYP3cide	Inhibitor	99.46%	Unkown
HY-117605	N-Desmethyl Sildenafil	Inhibitor	99.86%	Unkown
HY-113482	1β-Hydroxydeoxycholic acid		/	Unkown
HY-RS03474	CYP3A7 Human Pre-designed siRNA Set A		/	Unkown

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