CYP2C18 - cytochrome P450 family 2 subfamily C member 18 Gene

Homo sapiens

Also known as CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C

Gene ID: 1562 | Gene type: protein coding

About CYP2C18

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:94,683,729-94,736,190 (from NCBI)

This gene has 2 transcripts (splice variants), 49 orthologues and 15 paralogues. Biased expression in liver (RPKM 50.3), duodenum (RPKM 49.6) and 5 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CYP2C18 Products(2)

mRNA	Protein	Name
NM_000772.3	NP_000763.1	cytochrome P450 2C18 isoform 1 precursor
NM_001128925.2	NP_001122397.1	cytochrome P450 2C18 isoform 2 precursor

CYP2C18 Protein Structure

p450

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 2C18

(S)-mephenytoin hydroxylase associated cytochrome P450

Related Diseases

Diseases

Alias

Danubian Endemic Familial Nephropathy

Balkan Nephropathy	Balkan Endemic Nephropathy
Nephropathia Epidemica	Defn
Ben	Aristolochic Acid Nephropathy
Aan	Endemic Nephropathy Balkan
Balkan Nephritis

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Hemoglobin D Disease

Hb-D Disease	Punjab Disease
Los Angeles Disease	Hb D Los Angeles Disease
Hb D Punjab Disease

Plasmodium Ovale Malaria

Ovale Malaria

Malariaby Plasmodium Ovale

Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

Hemoglobin C Disease

Hb C Disease	Hemoglobin C
Hb-C Disease

Enterocele

Vaginal Enterocele	Hernia
Hernias

Prolapse Of Female Genital Organ

Median Neuropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03457	CYP2C18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP2C18	RGD	RGD:1563697

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