GRK3 - G protein-coupled receptor kinase 3 Gene

Homo sapiens

Also known as BARK2; ADRBK2

Gene ID: 157 | Gene type: protein coding

About GRK3

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:25,564,675-25,729,294 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues.

Summary

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta Adrenergic Receptor kinase 2 has 85% amino acid similarity with beta Adrenergic Receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GRK3 Products(2)

mRNA	Protein	Name
NM_001362778.2	NP_001349707.1	beta-adrenergic receptor kinase 2 isoform 2
NM_005160.4	NP_005151.2	beta-adrenergic receptor kinase 2 isoform 1

GRK3 Protein Structure

RGS

Pkinase

0
200
400
600
688 a.a.

Protein Preferred Names

Protein Names

beta-adrenergic receptor kinase 2

adrenergic, beta, receptor kinase 2

Related Diseases

Diseases

Alias

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05814	GRK3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRK3	VGNC	VGNC:62719
Bos taurus	GRK3	VGNC	VGNC:53904
Mus musculus	GRK3	MGD	MGI:87941
Rattus norvegicus	GRK3	RGD	RGD:2063
Macaca mulatta	GRK3	VGNC	VGNC:73255
Canis familiaris	GRK3	VGNC	VGNC:41503