2. Gene
  3. SLC5A12 - solute carrier family 5 member 12 Gene

SLC5A12 - solute carrier family 5 member 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SMCT2

Gene ID: 159963 | Gene type: protein coding

About SLC5A12

Cytogenetic location: 11p14.2 Genomic coordinates (GRCh38): 11:26,667,020-26,723,389 (from NCBI)

This gene has 5 transcripts (splice variants), 173 orthologues and 11 paralogues. Restricted expression toward kidney (RPKM 72.2).

Summary

Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]

SLC5A12 Products(1)

mRNA Protein Name
NM_178498.4 NP_848593.2 sodium-coupled monocarboxylate transporter 2

SLC5A12 Protein Structure

SSF

SSF: Sodium:solute symporter family (41 - 445)

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  • 618 a.a.
Protein Preferred Names Protein Names

sodium-coupled monocarboxylate transporter 2

electroneutral sodium monocarboxylate cotransporter

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13285 SLC5A12 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC5A12 RGD RGD:1311652
Felis catus SLC5A12 VGNC VGNC:65401
Macaca mulatta SLC5A12 VGNC VGNC:77787
Canis familiaris SLC5A12 VGNC VGNC:46445
Mus musculus SLC5A12 MGD MGI:2138890
Bos taurus SLC5A12 VGNC VGNC:34905