2. Gene
  3. DGKG - diacylglycerol kinase gamma Gene

DGKG - diacylglycerol kinase gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DAGK3; DGK-GAMMA

Gene ID: 1608 | Gene type: protein coding

About DGKG

Cytogenetic location: 3q27.2-q27.3 Genomic coordinates (GRCh38): 3:186,147,201-186,362,234 (from NCBI)

This gene has 11 transcripts (splice variants), 224 orthologues and 9 paralogues. Broad expression in brain (RPKM 8.0), heart (RPKM 3.6) and 15 other tissues.

Summary

This gene encodes an Enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DGKG Products(3)

mRNA Protein Name
NM_001080744.2 NP_001074213.1 diacylglycerol kinase gamma isoform 2
NM_001080745.2 NP_001074214.1 diacylglycerol kinase gamma isoform 3
NM_001346.3 NP_001337.2 diacylglycerol kinase gamma isoform 1

DGKG Protein Structure

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (3 - 175)

EF-hand_7

EF-hand_7: EF-hand domain pair (180 - 246)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (272 - 321)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (435 - 558)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (578 - 752)

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  • 791 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase gamma

DAG kinase gamma

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14

SCA14

Ataxia, Spinocerebellar, Type 14
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03719 DGKG Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DGKG VGNC VGNC:28028
Canis familiaris DGKG VGNC VGNC:39919
Mus musculus DGKG MGD MGI:105060
Macaca mulatta DGKG VGNC VGNC:71785
Felis catus DGKG VGNC VGNC:97399
Rattus norvegicus DGKG RGD RGD:2499