DGKQ - diacylglycerol kinase theta Gene

Homo sapiens

Also known as DAGK; DAGK4; DAGK7

Gene ID: 1609 | Gene type: protein coding

About DGKQ

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:958,887-973,569 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 9 paralogues. Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues.

Summary

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

DGKQ Products(1)

mRNA	Protein	Name
NM_001347.4	NP_001338.2	diacylglycerol kinase theta

DGKQ Protein Structure

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
800
942 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase theta

DAG kinase theta

Related Diseases

Diseases

Alias

Retinal Degeneration

Degeneration Of Retina

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03723	DGKQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DGKQ	VGNC	VGNC:28031
Mus musculus	DGKQ	MGD	MGI:102918
Felis catus	DGKQ	VGNC	VGNC:61463
Rattus norvegicus	DGKQ	RGD	RGD:2320722
Macaca mulatta	DGKQ	VGNC	VGNC:71788
Canis familiaris	DGKQ	VGNC	VGNC:39923

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