2. Gene
  3. Ikbkb - inhibitor of kappaB kinase beta Gene

Ikbkb - inhibitor of kappaB kinase beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IKK2; IKK-2; IKK[b]; IKKbeta; IKK-beta

Gene ID: 16150 | Gene type: protein coding

About Ikbkb

Chromosome 8: 23,149,228-23,196,605 reverse strand.GRCm39:CM001001.3

This gene has 14 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 32 phenotypes. Ubiquitous expression in spleen adult (RPKM 15.9), thymus adult (RPKM 12.5) and 28 other tissues.

Summary

Enables IkappaB kinase activity and protein Phosphatase binding activity. Involved in peptidyl-serine phosphorylation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ikbkb Products(2)

mRNA Protein Name
NM_001159774.1 NP_001153246.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1
NM_010546.2 NP_034676.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

Ikbkb Protein Structure

STKc_IKK_beta

STKc_IKK_beta: cd14038 (19 - 308)

Ubl_IKKA_like

Ubl_IKKA_like: cd17046 (309 - 389)

IKBKB_SDD

IKBKB_SDD: pfam18397 (388 - 662)

IKKbetaNEMObind

IKKbetaNEMObind: pfam12179 (705 - 741)

  • 0
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  • 757 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit beta

I-kappa-B kinase 2

I-kappa-B-kinase beta

IKK-B

NFKBIKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

nuclear factor NF-kappa-B inhibitor kinase beta

serine/threonine protein kinase IKBKB

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06659 Ikbkb Mouse Pre-designed siRNA Set A / Unkown
HY-RS06658 IKBKB Human Pre-designed siRNA Set A / Unkown
HY-RS06660 Ikbkb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikbkb NCBI NCBI:3551