2. Gene
  3. Il4 - interleukin 4 Gene

Il4 - interleukin 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il-4; BSF-1

Gene ID: 16189 | Gene type: protein coding

About Il4

Chromosome 11: 53,493,809-53,509,496 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 92 orthologues and is associated with 61 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 Products(1)

mRNA Protein Name
NM_021283.2 NP_067258.1 interleukin-4 precursor

Il4 Protein Structure

IL4_13

IL4_13: smart00190 (0 - 139)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

interleukin-4

B-cell IgG differentiation factor

B-cell growth factor 1

B-cell stimulatory factor 1

IGG1 induction factor

lymphocyte stimulatory factor 1

Recombinant Il4 Proteins

Cat. No. Product Name Accession Purity
HY-P7080 IL-4 Protein, Mouse (CHO) P07750 (H21-S140) ≥95%
HY-P70644 IL-4 Protein, Mouse P07750 (H23-S140) ≥95%
HY-P70653 IL-4 Protein, Mouse (HEK293, His) P07750 (H21-S140) ≥95%
HY-P73215 IL-4 Protein, Mouse (Q136D, Y139D, sf9, His) P07750 (M1-S140,Q136D,Y139D) ≥95%
HY-P700214AF Animal-Free IL-4 Protein, Mouse (His) P07750 (H21-S140) ≥95%
HY-P70653A IL-4 Protein, Mouse (HEK293, C-His) P07750 (H21-S140) ≥95%
HY-P701093 IL-4 Protein, Mouse (HEK293) P07750 (H21-S140) ≥95%

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0446 Naphazoline hydrochloride 98.37% Unkown
HY-17002 Suplatast (Tosilate) Inhibitor 98.33% Unkown
HY-108013 Armillarisin A 99.80% Unkown
HY-111326A Naphazoline nitrate ≥98.0% Unkown
HY-111326 Naphazoline / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9926 Dupilumab Inhibitor ≥99.2% Unkown
Clinical Phase
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 96.34% Phase 3
HY-P990090 Rademikibart Inhibitor / Phase 3
HY-P99724 Manfidokimab 95.00% Phase 2
HY-P99883 Romilkimab / Phase 2
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0527 Pentagalloylglucose Inhibitor 99.77% Unkown
HY-139092 IL-4-inhibitor-1 Inhibitor 98.14% Unkown
HY-126360 Oxazolone ≥98.0% Unkown
HY-134771 YM-341619 Inhibitor 99.06% Unkown
HY-N0600 Ginsenoside F3 Modulator 99.84% Unkown
HY-N3312 Matairesinol 98.33% Unkown
HY-N2426 Clerodendrin Inhibitor 99.66% Unkown
HY-N7652 Terminolic acid Inhibitor 99.63% Unkown
HY-15131 PNRI-299 Inhibitor / Unkown
HY-144683 PF-07038124 Inhibitor / Unkown
HY-116609 C6 L-threo Ceramide Inhibitor / Unkown
HY-125019 iJak-381 Inhibitor / Unkown
HY-141582 Ceramide 3 / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.32% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor / Unkown
HY-162404 Smad2/3-IN-2 Inhibitor / Unkown
HY-162405 Smad2/3-IN-1 Inhibitor / Unkown
HY-RS06765 IL4 Human Pre-designed siRNA Set A / Unkown
HY-RS06766 Il4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06767 Il4 Rat Pre-designed siRNA Set A / Unkown
HY-RS06768 IL4I1 Human Pre-designed siRNA Set A / Unkown
HY-RS06769 IL4R Human Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99238 Rolinsatamab Inhibitor 97.16% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il4 NCBI NCBI:3565
Macaca fascicularis Il4 NCBI NCBI:107130068
Susscrofa domestica Il4 NCBI
Rattus norvegicus Il4 NCBI NCBI:287287
Macaca mulatta Il4 NCBI NCBI:574281