2. Gene
  3. DEDD2 - death effector domain containing 2 Gene

DEDD2 - death effector domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FLAME3; FLAME-3

Gene ID: 162989 | Gene type: protein coding

About DEDD2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,198,598-42,220,134 (from NCBI)

This gene has 13 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.8), spleen (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

DEDD2 Products(3)

mRNA Protein Name
NM_001270614.2 NP_001257543.1 DNA-binding death effector domain-containing protein 2 isoform 1
NM_001270615.2 NP_001257544.1 DNA-binding death effector domain-containing protein 2 isoform 2
NM_133328.4 NP_579874.1 DNA-binding death effector domain-containing protein 2 isoform 1

DEDD2 Protein Structure

DED

DED: Death effector domain (26 - 109)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

DNA-binding death effector domain-containing protein 2

DED-containing protein FLAME-3

Related Diseases

Diseases Alias
Leukorrhea

Discharge - Leukorrhea

Leukorrhea Of Vagina
Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03670 DEDD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DEDD2 MGD MGI:1914629
Bos taurus DEDD2 VGNC VGNC:27985
Felis catus DEDD2 VGNC VGNC:61424
Macaca mulatta DEDD2 VGNC VGNC:109614
Canis familiaris DEDD2 VGNC VGNC:39873
Rattus norvegicus DEDD2 RGD RGD:1588968