DCTD - dCMP deaminase Gene

Homo sapiens

Gene ID: 1635 | Gene type: protein coding

About DCTD

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:182,890,091-182,917,611 (from NCBI)

This gene has 17 transcripts (splice variants), 245 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for Thymidylate Synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DCTD Products(9)

mRNA	Protein	Name
NM_001012732.2	NP_001012750.1	deoxycytidylate deaminase isoform a
NM_001351743.2	NP_001338672.1	deoxycytidylate deaminase isoform b
NM_001351744.2	NP_001338673.1	deoxycytidylate deaminase isoform b
NM_001351745.2	NP_001338674.1	deoxycytidylate deaminase isoform b
NM_001351747.2	NP_001338676.1	deoxycytidylate deaminase isoform b
NM_001351748.2	NP_001338677.1	deoxycytidylate deaminase isoform b
NM_001351750.2	NP_001338679.1	deoxycytidylate deaminase isoform b
NM_001351753.2	NP_001338682.1	deoxycytidylate deaminase isoform b
NM_001921.3	NP_001912.2	deoxycytidylate deaminase isoform b

DCTD Protein Structure

dCMP_cyt_deam_1

0
100
178 a.a.

Protein Preferred Names

Protein Names

deoxycytidylate deaminase

Related Diseases

Diseases

Alias

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03592	DCTD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCTD	VGNC	VGNC:71750
Canis familiaris	DCTD	VGNC	VGNC:39815
Bos taurus	DCTD	VGNC	VGNC:27927
Mus musculus	DCTD	MGD	MGI:2444529
Felis catus	DCTD	VGNC	VGNC:107325
Rattus norvegicus	DCTD	RGD	RGD:1359671