2. Gene
  3. Jun - jun proto-oncogene Gene

Jun - jun proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AP-1; Junc; c-jun

Gene ID: 16476 | Gene type: protein coding

About Jun

Chromosome 4: 94,937,271-94,940,459 reverse strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 226 orthologues, 2 paralogues and is associated with 63 phenotypes.

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. Acts upstream of or within several processes, including animal organ development; negative regulation of protein autophosphorylation; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products(1)

mRNA Protein Name
NM_010591.2 NP_034721.1 transcription factor Jun

Jun Protein Structure

Jun

Jun: pfam03957 (5 - 242)

bZIP_Jun

bZIP_Jun: cd14696 (256 - 316)

bZIP_Jun

bZIP_Jun: cd14696 (257 - 308)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

transcription factor Jun

AH119

AP1

Jun oncogene

V-jun avian sarcoma virus 17 oncogene homolog

activator protein 1

immediate early

jun A

proto-oncogene c-jun

transcription factor AP-1

transcription factor AP-1 subunit Jun

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-138304 CC-90001 Inhibitor 99.85% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12270 T-5224 Inhibitor 99.59% Unkown
HY-107598 JNK Inhibitor VIII Inhibitor 99.46% Unkown
HY-11010 AS601245 Inhibitor 98.83% Unkown
HY-W010983 SC-236 99.45% Unkown
HY-125838 J30-8 Inhibitor 99.90% Unkown
HY-148510 HKB99 Inhibitor 97.35% Unkown
HY-107599 AEG3482 Inhibitor 99.95% Unkown
HY-107600 IQ-3 Inhibitor 99.38% Unkown
HY-101287 MPT0B392 99.5% Unkown
HY-134975 NY2267 Inhibitor 99.34% Unkown
HY-P1190 c-JUN peptide / Unkown
HY-152142 DN-1289 Inhibitor / Unkown
HY-114250 Cantrixil Inducer 99.84% Yes
HY-107621 U0124 / Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-141582 Ceramide 3 / Unkown
HY-151928 JNK3 inhibitor-3 Inhibitor / Unkown
HY-155593 JNK-1-IN-2 Inhibitor / Unkown
HY-157403 Jun12682 / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS07054 JUN Human Pre-designed siRNA Set A / Unkown
HY-RS07055 Jun Mouse Pre-designed siRNA Set A / Unkown
HY-RS07056 Jun Rat Pre-designed siRNA Set A / Unkown
HY-157305 Jun11165 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jun NCBI NCBI:3725
Rattus norvegicus Jun NCBI NCBI:24516