TLE5 - TLE family member 5, transcriptional modulator Gene

Homo sapiens

Also known as AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5

Gene ID: 166 | Gene type: protein coding

About TLE5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,052,910-3,062,966 (from NCBI)

This gene has 12 transcripts (splice variants), 255 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TLE5 Products(3)

mRNA	Protein	Name
NM_001130.6	NP_001121.2	TLE family member 5 isoform b
NM_198969.1	NP_945320.1	TLE family member 5 isoform a
NM_198970.2	NP_945321.1	TLE family member 5 isoform c

TLE5 Protein Structure

TLE_N

0
100
197 a.a.

Protein Preferred Names

Protein Names

TLE family member 5

amino-terminal enhancer of split

Related Diseases

Diseases

Alias

Subendocardial Myocardial Infarction

Dental Anomalies And Short Stature

Brachyolmia-Amelogenesis Imperfecta Syndrome	Platyspondyly With Amelogenesis Imperfecta
DASS	Verloes Bourguignon Syndrome
Verloes-Bourguignon Syndrome	Vbs
Sthag6	Tooth Agenesis, Selective, 6
Tooth Agenesis, Selective, 6, Formerly	Sthag6, Formerly
Selective Tooth Agenesis 5	Amelogenesis Imperfecta And Platyspondyly
Skeletal Dysplasia With Amelogenesis Imperfecta And Platyspondyly	Platyspondyly-Amelogenesis Imperfecta Syndrome

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14567	TLE5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLE5	RGD	RGD:2731
Mus musculus	TLE5	MGD	MGI:95806