2. Gene
  3. DHX9 - DExH-box helicase 9 Gene

DHX9 - DExH-box helicase 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LKP; RHA; DDX9; NDH2; NDHII

Gene ID: 1660 | Gene type: protein coding

About DHX9

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,839,347-182,887,982 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 54.5), testis (RPKM 36.3) and 25 other tissues.

Summary

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an Enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

DHX9 Products(1)

mRNA Protein Name
NM_001357.5 NP_001348.2 ATP-dependent RNA helicase A

DHX9 Protein Structure

dsrm

dsrm: Double-stranded RNA binding motif (5 - 69)

dsrm

dsrm: Double-stranded RNA binding motif (181 - 250)

DEAD

DEAD: DEAD/DEAH box helicase (394 - 547)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (680 - 768)

HA2

HA2: Helicase associated domain (HA2) (831 - 919)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (959 - 1072)

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  • 1270 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase A

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9

Related Diseases

Diseases Alias
Werner Syndrome

Werner'S Syndrome

WRN

Adult Progeria

Ws

Adult Premature Ageing Syndrome

Adult Premature Aging Syndrome

Werners Syndrome
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Parkinson Disease 22, Autosomal Dominant

PARK22

Parkinson'S Disease 22

Autosomal Dominant Parkinson'S Disease 22

Parkinson Disease 22
Abnormal Retinal Correspondence
Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156784 DHX9-IN-2 Inhibitor 98.83% Unkown
HY-156782 DHX9-IN-1 Inhibitor 98.74% Unkown
HY-157602 DHX9-IN-8 Inhibitor / Unkown
HY-157603 DHX9-IN-7 Inhibitor / Unkown
HY-157604 DHX9-IN-9 Inhibitor / Unkown
HY-157605 DHX9-IN-11 Inhibitor / Unkown
HY-157606 DHX9-IN-13 Inhibitor / Unkown
HY-157607 DHX9-IN-15 Inhibitor / Unkown
HY-157608 DHX9-IN-10 Inhibitor / Unkown
HY-157609 DHX9-IN-12 Inhibitor / Unkown
HY-157610 DHX9-IN-14 Inhibitor / Unkown
HY-157611 DHX9-IN-17 Inhibitor / Unkown
HY-157612 DHX9-IN-16 Inhibitor / Unkown
HY-160007 DHX9-IN-3 Inhibitor / Unkown
HY-160008 DHX9-IN-4 Inhibitor / Unkown
HY-160009 DHX9-IN-5 Inhibitor / Unkown
HY-160010 DHX9-IN-6 Inhibitor / Unkown
HY-RS03761 DHX9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DHX9 MGD MGI:108177
Bos taurus DHX9 VGNC VGNC:28060
Felis catus DHX9 VGNC VGNC:61488
Rattus norvegicus DHX9 RGD RGD:1308548
Macaca mulatta DHX9 VGNC VGNC:71766
Canis familiaris DHX9 VGNC VGNC:39953