DEFA4 - defensin alpha 4 Gene

Homo sapiens

Also known as HP4; DEF4; HP-4; HNP-4

Gene ID: 1669 | Gene type: protein coding

About DEFA4

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,935,820-6,938,306 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 165 orthologues and 5 paralogues. Restricted expression toward bone marrow (RPKM 1355.2).

Summary

Defensins are a family of antimicrobial and cytotoxic Peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

DEFA4 Products(1)

mRNA	Protein	Name
NM_001925.3	NP_001916.1	defensin alpha 4 preproprotein

DEFA4 Protein Structure

Defensin_propep

Defensin_1

0
97 a.a.

Protein Preferred Names

Protein Names

defensin alpha 4

corticostatin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03675	DEFA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DEFA4	RGD	RGD:727857

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