2. Gene
  3. CRISP1 - cysteine rich secretory protein 1 Gene

CRISP1 - cysteine rich secretory protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARP; AEGL1; HUMARP; CRISP-1; HEL-S-57; HSCRISP1D; HSCRISP1G

Gene ID: 167 | Gene type: protein coding

About CRISP1

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,834,257-49,877,096 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 13 paralogues. Low expression observed in reference dataset.

Summary

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

CRISP1 Products(3)

mRNA Protein Name
NM_001131.3 NP_001122.2 cysteine-rich secretory protein 1 isoform 1 precursor
NM_001205220.2 NP_001192149.1 cysteine-rich secretory protein 1 isoform 1 precursor
NM_170609.2 NP_733758.1 cysteine-rich secretory protein 1 isoform 2 precursor

CRISP1 Protein Structure

CAP

CAP: Cysteine-rich secretory protein family (46 - 175)

Crisp

Crisp: Crisp (195 - 249)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

cysteine-rich secretory protein 1

AEG-like protein

Related Diseases

Diseases Alias
Diffuse Alopecia Areata

Diffuse Alopecia
Ectodermal Dysplasia 5, Hair/Nail Type

ECTD5

Ectodermal Dysplasia 5
Ectodermal Dysplasia 6, Hair/Nail Type

ECTD6

Ectodermal Dysplasia 6
Ectodermal Dysplasia 7, Hair/Nail Type

ECTD7

Ectodermal Dysplasia 7

Dysplasia, Ectodermal, Type 7, Hair/Nail
Epididymo-Orchitis
Necatoriasis

Miner'S Anaemia

Negro Cachexia

Dochmiasis

Ground Itch Disease

Brickmaker'S Chlorosis

Coolie Itch Anaemia

Cachexia Aquosa

Dew Itch Anaemia

Brickmaker'S Anaemia

Tunnel Worker'S Anaemia

Egyptian Anaemia

Tunnel Worker'S Disease

Miner'S Cachexia

Greisinger Disease

Tropical Chlorosis

Egyptian Chlorosis

Tunnel Anaemia

Dochmiosis

Necatorosis

African Cachexia

Water Itch Anaemia

Infection Due To Necator Americanus

St Gotthard Disease

Gotthard Tunnel Disease
Ectodermal Dysplasia 9, Hair/Nail Type

ECTD9

Ectodermal Dysplasia 9

Dysplasia, Ectodermal, Type 9, Hair/Nail
Tick Paralysis
Epididymis Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03179 CRISP1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CRISP1 MGD MGI:1925331
Rattus norvegicus CRISP1 RGD RGD:1590757
Bos taurus CRISP1 VGNC VGNC:27713
Macaca mulatta CRISP1 VGNC VGNC:81056
Felis catus CRISP1 VGNC VGNC:102409
Others CRISP1 NCBI