DEFA6 - defensin alpha 6 Gene

Homo sapiens

Also known as DEF6; HD-6

Gene ID: 1671 | Gene type: protein coding

About DEFA6

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,924,697-6,926,076 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 168 orthologues and 5 paralogues. Restricted expression toward small intestine (RPKM 3311.8).

Summary

Defensins are a family of antimicrobial and cytotoxic Peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

DEFA6 Products(1)

mRNA	Protein	Name
NM_001926.4	NP_001917.1	defensin-6 preproprotein

DEFA6 Protein Structure

Defensin_propep

Defensin_1

0
100 a.a.

Protein Preferred Names

Protein Names

defensin-6

defensin, alpha 6, Paneth cell-specific

Related Diseases

Diseases

Alias

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03677	DEFA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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