SYNPO2 - synaptopodin 2 Gene

Homo sapiens

Also known as SYISL

Gene ID: 171024 | Gene type: protein coding

About SYNPO2

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Broad expression in esophagus (RPKM 79.5), prostate (RPKM 71.0) and 14 other tissues.

Summary

Enables alpha-actinin binding activity and filamin binding activity. Involved in positive regulation of actin filament bundle assembly; positive regulation of cell migration; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in several cellular components, including Z disc; focal adhesion; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

SYNPO2 Products(7)

mRNA	Protein	Name
NM_001128933.3	NP_001122405.1	synaptopodin-2 isoform b
NM_001128934.3	NP_001122406.1	synaptopodin-2 isoform c
NM_001286754.2	NP_001273683.1	synaptopodin-2 isoform d
NM_001286755.2	NP_001273684.1	synaptopodin-2 isoform e
NM_001389263.1	NP_001376192.1	synaptopodin-2 isoform f
NM_001389264.1	NP_001376193.1	synaptopodin-2 isoform g
NM_133477.3	NP_597734.2	synaptopodin-2 isoform a

SYNPO2 Protein Structure

PDZ

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names

Protein Names

synaptopodin-2

SYNPO2 intron sense-overlapping lncRNA

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 23

NPHS23	Nephrotic Syndrome Type 23
Nephrotic Syndrome 23

Nephrotic Syndrome, Type 21

NPHS21	Nephrotic Syndrome Type 21
Nephrotic Syndrome 21

Nephrotic Syndrome, Type 22

NPHS22	Nephrotic Syndrome Type 22
Nephrotic Syndrome 22

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Myopathy, Myofibrillar, 2

Alpha-B Crystallinopathy	Myofibrillar Myopathy 2
MFM2	Myopathy, Myofibrillar, Alpha-B Crystallin-Related
Myopathy, Desmin-Related, Associated With Mutation In The Cryab Gene	Myopathy, Myofibrillar, With Or Without Cataract And/Or Cardiomyopathy
Alpha-B Crystallin-Related Late-Onset Myopathy	Alpha-B Crystallin-Related Late-Onset Distal Myopathy
Late-Onset Distal Crystallinopathy	Alpha-B Crystallinopathy With Cataract
Desmin-Related Myopathy With Cataract	Mfm Alpha-B Crystallin-Related
Myofibrillar Myopathy Alpha-B Crystallin-Related	Myofibrillar Myopathy With Or Without Cataract And/Or Cardiomyopathy
Myopathy Cardioskeletal Desmin-Related With Cataract	Myopathy Desmin-Related Associated With Mutation In The Cryab Gene
Myopathy, Cardioskeletal, Desmin-Related, With Cataract	Myopathy, Myofibrillar, Type 2

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14098	SYNPO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14099	SYNPO2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SYNPO2	VGNC	VGNC:78152
Rattus norvegicus	SYNPO2	RGD	RGD:1564779
Felis catus	SYNPO2	VGNC	VGNC:65889
Bos taurus	SYNPO2	VGNC	VGNC:35531
Canis familiaris	SYNPO2	VGNC	VGNC:47035
Mus musculus	SYNPO2	MGD	MGI:2153070

Name
Email *

	Sorry, but the email address you supplied was invalid.