DR1 - down-regulator of transcription 1 Gene

Homo sapiens

Also known as NC2; NC2B; NCB2; NC2-BETA

Gene ID: 1810 | Gene type: protein coding

About DR1

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,345,907-93,369,493 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 31.0), lymph node (RPKM 21.9) and 25 other tissues.

Summary

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

DR1 Products(1)

mRNA	Protein	Name
NM_001938.3	NP_001929.1	protein Dr1

DR1 Protein Structure

CBFD_NFYB_HMF

0
100
176 a.a.

Protein Preferred Names

Protein Names

protein Dr1

TATA-binding protein-associated phosphoprotein

Related Diseases

Diseases

Alias

Oesophagostomiasis

Infection By Oesophagostomum

Oesophagostomosis

Trichostrongylosis

Trichostrongyliasis	Infection By Trichostrongylus
Infection By Trichostrongylus Species	Trichostrongylus Infestation

Recessive Dystrophic Epidermolysis Bullosa

Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis	Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type
Rdeb, Hallopeau-Siemens Type	Severe Generalized Rdeb
Severe Generalized Recessive Dystrophic Epidermolysis Bullosa	Rdeb Generalisata Gravis
Rdeb, Severe Generalized	Rdeb-Sev Gen
Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized	Hallopeau-Siemens Disease

Epidermolysis Bullosa Dystrophica, Pretibial

Epidermolysis Bullosa, Pretibial	Pretibial Dystrophic Epidermolysis Bullosa
Deb-Pt	Dystrophic Epidermolysis Bullosa, Pretibial
Deb, Pretibial	Pretibial Epidermolysis Bullosa
Pretibial Deb	Localized Dystrophic Epidermolysis Bullosa, Pretibial Form
Localized Deb, Pretibial Form	Epidermolysis Bullosa Dystrophica, Pretibial Type
PR-DEB

Corneal Dystrophy, Subepithelial Mucinous

Subepithelial Mucinous Corneal Dystrophy

SMCD

Spondyloepimetaphyseal Dysplasia, Strudwick Type

Spondylometaphyseal Dysplasia	Strudwick Syndrome
Dappled Metaphysis Syndrome	Semd, Strudwick Type
Spondylometaepiphyseal Dysplasia Congenita, Strudwick Type	Smed, Strudwick Type
Smd	Smed Strudwick Type
SEMDSTWK	Smed, Type I
Semdc	Smed Type 1
Spondyloepimetaphyseal Dysplasia Strudwick Type	Sed Strudwick
Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type	Smed Type I
Spondyloepiphyseal Dysplasia Congenita With Dappled Metaphyses	Dysplasia, Spondyloepimetaphyseal, Strudwick Type
Dysplasia, Spondylometaphyseal

Trichostrongyloidiasis

Anisakiasis

Infection By Anisakis Larva	Anisakis Infection
Pseudoterranova Infection	Anisakiasis Due To Anisakis Simplex
Anisakiasis Due To Pseudoterranova Decipiens	Anisakis Infestation
Infection Due To Anisakis Larvae

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Ancylostomiasis

Ankylostomiasis	Hookworm Infection
Hookworm Infections	Ancylostomiasis Due To Ancylostoma Duodenale
Ancylostoma Duodenale Infection

Transient Bullous Dermolysis Of The Newborn

TBDN	Transient Bullous Of The Newborn
Epidermolysis Bullosa Dystrophica, Neonatal Form	Dystrophic Epidermolysis Bullosa, Neonatal
Deb, Bullous Dermolysis Of The Newborn	Deb-Bdn
Epidermolysis Bullosa Dystrophica, Dominant Neonatal Form	Self-Improving Dystrophic Epidermolysis Bullosa
Self-Improving Deb	Epidermolysis Bullosa Dystrophica Dominant Neonatal Type

Traumatic Glaucoma

Glaucoma Associated With Ocular Trauma

Epidermolysis Bullosa Dystrophica

Dystrophic Epidermolysis Bullosa	Deb
Dermolytic Epidermolysis Bullosa	Epidermolysis Bullosa, Dermolytic
Epidermolysis Bullosa, Dystrophic	Epidermolysis Bullosa Dystrophic
Dystrophic Eb - [Epidermolysis Bullosa]

Internal Hordeolum

Noonan Syndrome 2

NS2	Noonan Syndrome, Autosomal Recessive
Noonan Syndrome 2, Autosomal Recessive	Noonan Syndrome, Type 2

Hypoparathyroidism-Deafness-Renal Disease Syndrome

Barakat Syndrome	Hypoparathyroidism, Deafness, Renal Disease Syndrome
Hdr Syndrome	Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

Acquired Color Blindness

Acquired Color Vision Deficiencies	Acquired Color Vision Deficiency
Acquired Colour Blindness	Acquired Colour Vision Deficiencies
Acquired Colour Vision Deficiency

Toxocariasis

Toxocara Infection	Visceral Larva Migrans
Larva Migrans, Visceral	Infection By Toxascaris
Larva Migrans Visceral	Larva Migrans Visceralis
Toxocaral Visceral Larva Migrans	Visceral Larva Migrans Syndrome
Toxocara Infestation

Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous

Epithelial And Subepithelial Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150069	UBX1325		≥98.0%	Unkown
HY-139170	CAY10746	Inhibitor	99.77%	Unkown
HY-157269	J10-1		/	Unkown
HY-RS03986	DR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DR1	VGNC	VGNC:80190
Mus musculus	DR1	MGD	MGI:1100515
Bos taurus	DR1	VGNC	VGNC:28200
Rattus norvegicus	DR1	RGD	RGD:1305201
Canis familiaris	DR1	VGNC	VGNC:40087
Others	DR1	NCBI

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