2. Gene
  3. Nos1 - nitric oxide synthase 1, neuronal Gene

Nos1 - nitric oxide synthase 1, neuronal Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

Gene ID: 18125 | Gene type: protein coding

About Nos1

Chromosome 5: 117,919,097-118,096,905 forward strand.GRCm39:CM000998.3

This gene has 7 transcripts (splice variants), 198 orthologues, 5 paralogues and is associated with 113 phenotypes. Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 4.) and 12 other tissues.

Summary

Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in heart process; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nos1 Products(1)

mRNA Protein Name
NM_008712.3 NP_032738.1 nitric oxide synthase, brain

Nos1 Protein Structure

PDZ_signaling

PDZ_signaling: cd00992 (14 - 97)

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (299 - 710)

Flavodoxin_1

Flavodoxin_1: pfam00258 (756 - 929)

Nitric_oxide_synthase

Nitric_oxide_synthase: cd06202 (995 - 1398)

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  • 1429 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, brain

NOS type I

constitutive NOS

neuronal NOS

neuronal nitric oxide synthase

peptidyl-cysteine S-nitrosylase NOS1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6607 Tryptanthrin 99.89% Unkown
HY-107720 ARL 17477 Inhibitor 99.02% Unkown
HY-12117 L-NIL hydrochloride Inhibitor / Unkown
HY-124996 (Rac)-ZLc-002 Inhibitor 98.96% Unkown
HY-130452 NOS1-IN-1 Inhibitor ≥95.0% Unkown
HY-RS09433 NOS1 Human Pre-designed siRNA Set A / Unkown
HY-RS09434 Nos1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09435 Nos1 Rat Pre-designed siRNA Set A / Unkown
HY-RS09436 NOS1AP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos1 NCBI NCBI:4842